2021

Carrizo V., Valenzuela C.A., Zuloaga R., Aros C., Altamirano C., Valdés J.A., Molina A. Effect of cortisol on the immune-like response of rainbow trout (Oncorhynchus mykiss) myotubes challenged with Piscirickettsia salmonis. Veterinary Immunology and Immunopathology, Volume 237, 110240.

https://doi.org/10.1016/j.vetimm.2021.110240

Carrizo V., Valenzuela C.A., Aros C., Dettleff P, Valenzuela-Muñoz V., Gallardo-Escarate C., Altamirano C., Molina A., Valdés J.A. Transcriptomic analysis reveals a Piscirickettsia salmons- induces early inflammatory response in rainbow trout skeletal muscle.Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, Volume 39, 100859.

https://doi.org/10.1016/j.cbd.2021.100859

2020

Dettleff P., Villagra M., González J., Fuentes M., Estrada J.M, Valenzuela C.A., Molina A., Valdés J.A. Effect of bacterial LPS, poly I:C and temperature on the immune response of coelomocytes in short term cultures of red sea urchin (Loxechinus albus). Fish Shellfish Immunol. 107, 187-193.

doi: 10.1016/j.fsi.2020.09.028.

Valenzuela, C.A., Ponce, C., Zuloaga, R. Gonzales P., Avendaño-Herrera R., Valdés J. A., Molina A. Effects of crowding on the three main proteolytic mechanisms of skeletal muscle in rainbow trout (Oncorhynchus mykiss). BMC Vet Res 16,294.

doi: 10.1186/s12917-020-02518-w

2019

Bethke J., Arias-Muñoz E., Yañez A., Avendaño-Herrera R. Renibacterium salmoninarum iron acquisition mechanisms and ASK cell line infection: Virulence and immune response. Journal of Fish Diseases, 42, 1283-1291. 

doi: 10.1111/jfd.13051

Valenzuela CA, Escobar-Aguirre S, Zuloaga R, Vera-Tobar T, Mercado L, Björnsson BT, Valdés JA, Molina A. Stocking density induces differential expression of immune-related genes in skeletal muscle and head kidney of fine flounder (Paralichthys adspersus). Vet Immunol Immunopathol 210, 23-27.

doi: 10.1016/j.vetimm.2019.03.004.

González·P., Dettlef·P., Valenzuela·C.A. Estrada · J.M., Valdés ·J.A., Meneses· C., Molina A. Evaluating the genetic structure of wild and commercial red cusk‑eel (Genypterus chilensis) populations through the development of novel microsatellite markers from a reference transcriptome. Mol. Biol. Rep. 46, 5875–5882.

doi:10.1007/s11033-019-05021-0

2018

Cristián A. Valenzuela, Rodrigo Zuloaga, Luis Mercado, Ingibjörg Eir Einarsdottir, Björn Thrandur Björnsson, Juan Antonio Valdés, and Alfredo Molina. Chronic stress inhibits growth and induces proteolytic mechanisms through two different nonoverlapping pathways in the skeletal muscle of a teleost fish. Am J Physiol Regul Integr Comp Physiol 314, 102–113.

doi: 10.1152/ajpregu.00009.2017.

Katterinne N. Mendeza, Rodrigo Zuloaga, Cristián A.Valenzuela, Macarena Bastias-Molina, ClaudioMeneses, PaulaVizoso, Juan AntonioValdés, Alfredo Molina.RNA-seq analysis of compensatory growth in the skeletal muscle of fine flounder (Paralichthys adspersus). Aquaculture. 490, 270-280.

doi: 10.1016/j.aquaculture.2018.02.048.

Bethke J., Yañez A., Avendaño-Herrera R. Comparative Genomic Analysis of two Chilen Renibacterium salmoninarum Isolates and the type strain ATCC 33209T. Genome Biology and Evolution, evy138.

doi:10.1093/gbe/evy138.

González-Aravena M., Calfio C., Mercado L., Morales-Lange B., Bethke J., De Lorgeril J., Cardenas CA. HSP70 from the Antarctic sea urchin Sterechinus neumayeri: molecular characterization and expression in response to heat stress. Biol. Res. 51:8.

doi: 10.1186/s40659-018-0156-9

2017

Cristián A. Valenzuela, Rodrigo Zuloaga, Luis Mercado, Ingibjörg Eir Einarsdottir, Björn Thrandur Björnsson, Juan Antonio Valdés & Alfredo Molina. Chronic stress inhibits growth and induces proteolytic mechanisms through two different non-overlapping pathways in the skeletal muscle of a teleost fish.  American Journal of Physiology – Regulatory, Integrative and Comparative Physiology Published 4 October 2017.

doi:10.1152/ajpregu.00009.2017 

Cristián A. Valenzuela, Rodrigo Zuloaga, Luis Mercado, Juan Antonio Valdes, Ruben Avendaño-Herrera & Alfredo Molina. Fish skeletal muscle tissue is an important focus of immune reactions during pathogen infection. 

doi:10.1016/j.dci.2017.03.004.

Bethke J. & Avendaño-Herrera R. Comparative genome analysis of two Streptococcus phocae subspecies provides novel insights into pathogenicity.  Marine Genomics 31.

doi: 10.1016/j.margen.2016.09.005.

Bethke J., Quezada J., Poblete-Morales M., Irgang R., Yáñez A., Oliver C. and Avendaño-Herrera R.Biochemical, serological, and genetic characterization of Renibacterium salmoninarum isolates recovered from salmonids in Chile. Bull. Eur. Ass. Fish Pathol, 37(4), 169.

2016

Espinoza, M. B., Aedo, J. E., Zuloaga, R., Valenzuela, C., Molina, A. and Valdés, J. A.Cortisol Induces Reactive Oxygen Species Through a Membrane Glucocorticoid Receptor in Rainbow Trout Myotubes. J. Cell. Biochem.  

doi:10.1002/jcb.25676

Iron acquisition and siderophore production in the fish pathogen Renibacterium salmoninarum. Bethke J., Poblete-Morales M., Irgang R., Yañez A. & Avendaño-Herrera R. Journal of Fish Diseases 2016

doi:10.1111/jfd.12456.

Jorn Bethke, Rute Irgang, Matías Poblete-Morales, Alejandro Yañez & Ruben Avendaño-Herrera. Usos de antibióticos y vacunas contra BKD: Antecedentes y Proyecciones.  Salmonexpert 40:5, 42-45.

2015

Andrea Retamales; Rodrigo Zuloaga; Cristian Valenzuela; Cristian Gallardo; Alfredo Molina; Juan Antonio Valdes. Insulin-like Growth Factor-1 suppresses the Myostatin signaling pathway during myogenic differentiation.  Journal of Biochemical and Biophysical Research Communications (BBRC). doi: 10.1016/j.bbrc.2015.07.018.

Cristian A. Valenzuela, Daniela Escobar, Lorena Perez, Rodrigo Zuloaga, Juan Manuel Estrada, Luis Mercado, Juan Antonio Valedes& Alfredo Molina.Transcriptional dynamics of immune, growth and stress related genes in skeletal muscle of the Fine flounder (Paralichthysadpersus) during different nutritional statuses.  Developmental and Comparative Immunology.

doi: 10.1016/j.dci.2015.06.007.

Gonzalez-Aravena M., Perez-Troncoso C., Urtubia R., Branco P., Machado Cunha da Silva JR., Mercado L., De Lorgeril J., Bethke J. & Paschke K. Immune response of the Antarctic sea urchin Sterechinus neumayeri: cellular, molecular and physiological approach.  Revista de Biología Tropical, 63.

doi: 10.15517/rbt.v63i2.23165

Phenotypical parameters as a tool to evaluate the immunostimulatory effects of laminarin in Oncorhynchus mykiss.Morales-Lange B., Bethke J., Schmitt P. & Mercado LAquaculture Research, 2015, 46, 2707–2715.  

doi:10.1111/are.12426

Jorn Bethke, Alejandro Yáñez & Ruben Avendaño-Herrera. Renibacterium salmoninarum y sus mecanismos de virulencia: El nuevo desafío de la salmonicultura chilena. Salmonexpert 6:55-57.

Jorn Bethke, Jaime Figueroa, Alejandro Yáñez, Ruben Avendaño-Herrera. Perspectivas del conocimiento en la era genómica de Piscirickettsia salmonis  Salmonexpert 4:66-68.

2013

Bethke J., Barría A., Cabrejos ME., Guzmán F., Mercado L. Development of an ELISA sandwich assay for quantifying IFN-gamma in salmonids. . Conference abstract in Fish & Shellfish Immunology. 34:6, June 2013, Pages 1696-1697.

Schmitt, B. Morales-Lange, J. Bethke, L. Mercado. Immunostimulatory effect of β-glucans in rainbow trout (Oncorhynchus mykiss). Conference abstract in Fish& Shellfish Immunology. 34:6, June 2013, Pages 1736-1737.

2012

Bethke J., Rojas MV., Berendsen J., Cárdenas C., Guzmán F., Gallardo JA. & Mercado L. Development of a new antibody for detecting Natural killer enhancing factor (NKEF)-like in infected salmonids.  Journal of Fish Diseases. 2012, 35, 379–388.

doi: 10.1111/j.1365-2761.2012.01354.x

Verónica Rojas, Fanny Guzmán, Cristián Valenzuela, Sergio H. Marshall and Luis Mercado. Development of a caspase-3 antibody as a tool for detecting apoptosis in cells from rainbow trout (Oncorhynchusmykiss). ElectronicJournal of Biotechnology.

doi: 10.2225/vol15-issue5-fulltext-16.